Endocrine Abstracts

Background: Optimal testing of beta-cell dysfunction is still elusive. Oral based solid-food tests could superiorly approximate real-life stimulation by incorporating incretin activation. Increased body fat was recently associated with better preserved beta-cell secretory response, due to gluco-lipotoxicity induced adaptation.Objective: To assess C-peptide response to standardised test meal (STM) and its dependency on subject characteristics in newly dia...

Background: Vascular complications are leading cause of increased morbidity and mortality of diabetic patients. Pathophysiological mechanisms included in the development and progression of diabetic complications are various and lately it has been postulated that matrix metalloproteinases MMP-2 and MMP-9, zinc-dependent endopeptidases through remodeling of extracellular matrix can contribute to the onset and progression of diabetic vascular complications. The aim of our study w...